Anti-inflammatory alkaloids from the cold-seep-derived fungus Talaromyces helicus SCSIO41311.

Abstract

One new natural alkaloid, chaetominine B (1), together with twenty known compounds was isolated from the South China Sea cold-seep-derived fungus Talaromyces helicus SCSIO41311. Their structures were elucidated on the basis of nuclear magnetic resonance spectrum (NMR), mass spectrometry (MS) and ECD calculation, as well as comparing with previous literatures. Among them, twelve compounds showed potent NO inhibitory activities and two of them, azaspirofurans A (13) and fumiquinones B (21), exhibited NO inhibitory effects more than the positive control eicosapentaenoic acid (EPA) with IC(50) values of 9.65 and 15.54 μM, respectively. Moreover, compound 13 attenuated LPS-induced imbalance of cytokines release such as TNF-α, IL-1β, IL-4, and IL-10. Additionally, the NMR data and absolute configuration of compound 20 were first reported.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s13205-022-03237-9.